Article Publish Status: FREE
Abstract Title:

Evaluation of Antineoplasic Activity of Zingiber Officinale Essential Oil in the Colorectal Region of Wistar Rats.

Abstract Source:

Asian Pac J Cancer Prev. 2020 Jul 1 ;21(7):2141-2147. Epub 2020 Jul 1. PMID: 32711443

Abstract Author(s):

Daniel Augusto Nunes De Lima, Brenda Barroso Pelegrini, Felipe Alexandre Alves Uechi, Raíssa Coracini Varago, Bruno Bueno Pimenta, Alice Maria De Souza Kaneshima, Edilson Nobuyoshi Kaneshima, Paola Da Costa Souza, Raíssa Bocchi Pedroso, Thaís Gomes Verzignassi Silveira, Tânia Cristina Alexandrino Becker

Article Affiliation:

Daniel Augusto Nunes De Lima


INTRODUCTION: Aberrant Crypt (AC) and Aberrant Crypt Focus (ACF) are considered pre-neoplasic lesions, ranging from hyperplasia to different degrees of dysplasia in the colon. This work aimed to evaluate and quantify the chemopreventive activity of Zingiber officinale essential oil in the colorectal region of Wistar rats.

MATERIALS AND METHODS: We extracted the essential oil from ginger rhizomes and carried out ACF induction, in rats, with 1.2 Dimethylhydrazine (DMH) at a 20 mg/kg dose. The experimental groups were GI (negative control); GII (positive induction control); GIII (DMH + essential oil); GIV (DMH +5-Florouracil) and GV (essential oil). The histological techniques used were methylene blue, hematoxylin-eosin (HE) dyeing, and immunohistochemistry (IHQ).

RESULTS: The major essential oil compounds were citral (17.25%),δ-citral (10.25%), camphene (9.55%), α-zingiberene (7.57%), nerol (6.37%) and plelandrene (6.83%). For the presence of AC or ACF, we did not observe them in GI and GV, while in GII and GIII, they were observed, in high values, in both regions, but only in the distal region, there was a significantdifference between them. For GIV, for both regions, there were significant lower numbers of AC when compared to GIII. As observed, with HE, there were hyperplastic and dysplastic ACF in the proximal and distal portions of the colon. For IHQ analyses, there were positively PCNA antibody marked cellsin all experimental groups. Yet, there was no significant correlation of mitotic index among them. Moreover, the results of GIII compared to GIV were very similar.

CONCLUSION: In this sense, the Zingiber officinale essential oil has good antioxidant potential because it presents a mixture of monoterpene and sesquiterpene compounds. Thus, it is able to develop a chemoprotective effect, as it presented similar results to the standard drug, showing cell proliferation control.

Study Type : Animal Study

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