Article Publish Status: FREE
Abstract Title:

Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer.

Abstract Source:

Turk J Med Sci. 2021 Feb 8. Epub 2021 Feb 8. PMID: 33550763

Abstract Author(s):

FÜsun Erten, Engİn Yenİce, Cemal Orhan, BeŞİr Er, Pinar Demİrel Öner, Patrick Brice Defo Deeh, Kazİm Şahİn

Article Affiliation:

FÜsun Erten


BACKGROUND/AIM: Numerous studies show that cancer risk is reduced by consumption of soy-based foods containing genistein, but its effects on the glycogen synthase kinase-3 pathway (GSK-3) in ovarian cancer is unknown. Therefore, we tested the properties of genistein on inflammatory biomarkers and GSK-3 signaling pathways in the ovaries of old laying hens with ovarian cancer.

MATERIALS AND METHODS: A total of 300 laying hens were distributed into 3 groups as follows: group 1, animals fed a standard diet (comprising 22.39 mg of genistein/kg of diet); groups 2 and 3, animals fed a standard diet reconstituted with supplementation of 400 mg or 800 mg of genistein/kg of diet, respectively.

RESULTS: Genistein modulated the inflammatory biomarkers by decreasing serum tumor necrosis factor-? (TNF-?), interleukin-6 (IL-6), interleukin-8 (IL-8), and vascular endothelial growth factor (VEGF) compared with control (P<0.001). Moreover, genistein up-regulated insulin receptor substrate-1 (p-IRS-1) and protein kinase B (p-AKT), but down-regulated GSK-3? andß after treatment. Genistein acts in a dose-dependent manner.

CONCLUSION: Genistein exhibited an anticancer effect by reducing pro-inflammatory biomarkers levels and inhibiting GSK-3 expression in the ovaries of old laying hens. Genistein is a potential candidate in the chemoprevention and/or treatment of ovarian cancer.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.