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Article Publish Status: FREE
Abstract Title:

Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer.

Abstract Source:

Turk J Med Sci. 2021 Feb 8. Epub 2021 Feb 8. PMID: 33550763

Abstract Author(s):

FÜsun Erten, Engİn Yenİce, Cemal Orhan, BeŞİr Er, Pinar Demİrel Öner, Patrick Brice Defo Deeh, Kazİm Şahİn

Article Affiliation:

FÜsun Erten

Abstract:

BACKGROUND/AIM: Numerous studies show that cancer risk is reduced by consumption of soy-based foods containing genistein, but its effects on the glycogen synthase kinase-3 pathway (GSK-3) in ovarian cancer is unknown. Therefore, we tested the properties of genistein on inflammatory biomarkers and GSK-3 signaling pathways in the ovaries of old laying hens with ovarian cancer.

MATERIALS AND METHODS: A total of 300 laying hens were distributed into 3 groups as follows: group 1, animals fed a standard diet (comprising 22.39 mg of genistein/kg of diet); groups 2 and 3, animals fed a standard diet reconstituted with supplementation of 400 mg or 800 mg of genistein/kg of diet, respectively.

RESULTS: Genistein modulated the inflammatory biomarkers by decreasing serum tumor necrosis factor-? (TNF-?), interleukin-6 (IL-6), interleukin-8 (IL-8), and vascular endothelial growth factor (VEGF) compared with control (P<0.001). Moreover, genistein up-regulated insulin receptor substrate-1 (p-IRS-1) and protein kinase B (p-AKT), but down-regulated GSK-3? andß after treatment. Genistein acts in a dose-dependent manner.

CONCLUSION: Genistein exhibited an anticancer effect by reducing pro-inflammatory biomarkers levels and inhibiting GSK-3 expression in the ovaries of old laying hens. Genistein is a potential candidate in the chemoprevention and/or treatment of ovarian cancer.

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