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Article Publish Status: FREE
Abstract Title:

Ginsenoside Rb1 Alleviated High-Fat-Diet-Induced Hepatocytic Apoptosis via Peroxisome Proliferator-Activated Receptor.

Abstract Source:

Biomed Res Int. 2020 ;2020:2315230. Epub 2020 Jul 13. PMID: 32733933

Abstract Author(s):

Bing Song, Yao Sun, Yafen Chu, Jing Wang, Hongwei Zheng, Lili Liu, Wang Cai, Haoqiang Zhang

Article Affiliation:

Bing Song

Abstract:

Objective: High-fat-diet- (HFD-) induced hepatic cell apoptosis is common in mice with nonalcoholic fatty liver disease (NAFLD). We aim to investigate the effect of Ginsenoside Rb1 (GRb1) on hepatocyte apoptosis.

Methods: C57BL/6J mice with HFD were used to induce a liver-injured model with cell apoptosis. In addition, GRb1 was used to treat HFD-induced apoptosis in a liver with or without inhibitor of peroxisome proliferator-activated receptor(PPAR-).

Results: Compared with C57BL/6J mice with common chow, there are downregulated PPAR-but upregulated cell apoptosis in the liver of mice with HFD. Furthermore, GRb1 elevated the hepatic PPAR-level and suppressed hepatocytic apoptosis. However, GW9662 abolished the effects of GRb1 on apoptosis in the liver.

Conclusions: GRb1 alleviated HFD-induced apoptosis of hepatocytes of mice via PPAR-.

Study Type : Animal Study

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Sayer Ji
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