Abstract Title:

Identification andα-Glucosidase Inhibitory Activity of Meroterpenoids from Hericium erinaceus.

Abstract Source:

Planta Med. 2020 May ;86(8):571-578. Epub 2020 Apr 21. PMID: 32325508

Abstract Author(s):

Baosong Chen, Junjie Han, Li Bao, Wenzhao Wang, Ke Ma, Hongwei Liu

Article Affiliation:

Baosong Chen


is a very popular edible and medicinal mushroom used for the treatment of enervation and gastrointestinal diseases in Eastern Asia. Chemical investigation on the fruiting body ofled to the isolation of 4 new (1: - 4: ) and 10 known meroterpenoids (5:  - 14: ). The structures of new compounds were determined via analysis of NMR and MS data in combination with chemical derivatization. The inhibitory activities of 1:  - 14: against-glucosidase were evaluated using-nitrophenyl--D-glucopyranoside, sucrose, or maltose as substrate. Compounds 6, 9, 11: - 13: were demonstrated to show the-glucosidase inhibitory activities. This work confirms the potential ofin the treatment of diabetes.

Study Type : In Vitro Study

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