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Article Publish Status: FREE
Abstract Title:

Identification of compounds with antipyretic effects and anti-endotoxin activity in different species ofusing spectrum-effect correlation.

Abstract Source:

Exp Ther Med. 2021 Jul ;22(1):665. Epub 2021 Apr 22. PMID: 33986830

Abstract Author(s):

Jing-Xin Ding, Chang Liu, Xiong-Wei Liu, Wei-Na Yan, Wen-Pei Li, Hui Shi, Jia-Xin Li, Cheng-Lin Tang, Ying Zhou

Article Affiliation:

Jing-Xin Ding

Abstract:

Liquid chromatography (LC) is a common and straight forward approach used in the evaluation of the quality of Traditional Chinese Medicines (TCMs). Quality control is a critical step when systematically assessing the efficacy of TCMs. In the present study, the spectrum-effect correlation method was used to identify pharmacologically active substances. The aim of the present study was to investigate the underlying correlations between common chemical compounds with antipyretic effects and the anti-endotoxin activity of. The common chemical constituents ofwere analyzed using LC, and the antipyretic effects and anti-endotoxin activity were determined using ELISAs. Combining the results of bivariate and principal component analysis methods, eight active constituents were qualitatively and quantitatively analyzed. The results of these analyses indicated that neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and isochlorogenic acids A, B and C served a synergistic role with respect to antipyretic effects and anti-endotoxin activity. The present study lays a foundation for the future clinical use of.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Anti-pyretic : CK(62) : AC(24)

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