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Abstract Title:

L-theanine suppresses the metastasis of prostate cancer by downregulating MMP9 and Snail.

Abstract Source:

J Nutr Biochem. 2021 03 ;89:108556. Epub 2020 Nov 26. PMID: 33249185

Abstract Author(s):

Xirui Fan, Jinyi Zhou, Xiaowen Bi, Juanjuan Liang, Shuai Lu, Xintong Yan, Lan Luo, Zhimin Yin

Article Affiliation:

Xirui Fan

Abstract:

Prostate cancer (PCa) is a very prevalent male-specific malignancy; most PCa patients eventually die as a result of metastasis. L-theanine (C7H14N2O3), a nonprotein amino acid derivative from green tea leaves, has been demonstrated to act as an anticarcinogen through proapoptotic and antiproliferative effects. However, the antimetastatic effect of L-theanine in tumor cells and its underlying mechanism are still unclear. Here, we found that L-theanine could suppress invasion, migration, and increase cell-cell adhesion of prostate cancer cells in vitro and in vivo. We also found that L-theanine could inhibit the epithelial-mesenchymal transition process in PCa. Our study revealed that L-theanine could downregulate MMP9, N-cadherin, Vimentin, Snail, and upregulate E-cadherin. Furthermore, L-theanine suppressed the transcription of MMP9 and Snail by significantly inhibiting the ERK/NF-κB signaling pathway and the binding activity of p65 to the promoter regions of MMP9 and Snail. All of these findings suggest that L-theanine has therapeutic potential for metastatic PCa and may be considered a promising candidate for antimetastatic therapy of prostate cancer.

Study Type : Animal Study, In Vitro Study

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