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Article Publish Status: FREE
Abstract Title:

Mechanism of action of glycyrrhizin against Plasmodium falciparum.

Abstract Source:

Mem Inst Oswaldo Cruz. 2021 ;116:e210084. Epub 2021 Aug 20. PMID: 34431854

Abstract Author(s):

Maria de Nazaré Correia Soeiro, Gérard Vergoten, Christian Bailly

Article Affiliation:

Maria de Nazaré Correia Soeiro

Abstract:

Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified three main mechanisms at the origin of their anti-plasmodial activity: (i) drug-induced disorganisation of membrane lipid rafts, (ii) blockade of the alarmin protein HMGB1 and (iii) potential inhibition of the detoxifying enzyme glyoxalase 1 (GLO-1) considered as an important drug target for malaria. Our analysis shed light on the mechanism of action of GLR against P. falciparum.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antimalarials : CK(90) : AC(53)

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