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Abstract Title:

Morin exhibits leukemic cellular apoptosis through caspase pathway.

Abstract Source:

Nat Prod Res. 2020 Jul 16:1-5. Epub 2020 Jul 16. PMID: 32674703

Abstract Author(s):

Wander Lopes Pereira, Tânia Toledo de Oliveira, Milton Masahiko Kanashiro, Marcelo Augusto Filardi, Marcelo Rocha da Costa, Liovando Marciano da Costa

Article Affiliation:

Wander Lopes Pereira

Abstract:

The present study investigated the possibility of apoptosis-inducing activity in human leukemia U-937 and THP-1 cells by the flavonoid morin. The treatments were evaluated by using the MTT and LDH assays; analysis of mitochondrial membrane potential (ΔΨm) was evaluated by flow cytometry, cell death by apoptosis was confirmed by fluorescence microscopy and by assessing the activity of caspases-3 and -6. The data indicated that the flavonoid morin has promoted a decrease in cell viability in a concentration-dependent way for both of the cancerous cell lines. An increase in the percentage of cell death caused by apoptosis was associated to a potential alteration in the mitochondrial membrane (ΔΨm) suggesting the involvement of cell death in intrinsic apoptotic pathways. Activation of caspases-3 and -6 confirmed the presence of apoptotic activity from morin. The results reinforce the antileukemic potential of flavonol morin.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(6986) : AC(5304)

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Sayer Ji
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