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Abstract Title:

Nobiletin ameliorates streptozotocin-cadmium-induced diabetic nephropathyNF-κB signalling pathway in rats.

Abstract Source:

Arch Physiol Biochem. 2021 Aug 4:1-9. Epub 2021 Aug 4. PMID: 34346259

Abstract Author(s):

Mingzhu Xu, Ruifang Wang, Hui Fan, Ziyuan Ni

Article Affiliation:

Mingzhu Xu

Abstract:

This study sought to examine the anti-diabetic effect of nobiletin on streptozotocin (STZ)/cadmium (Cd)-induced diabetic nephrotoxic (DN) rats. The DN was induced using STZ (40 mg/kg b.w) intraperitoneally and Cd through drinking water for 12 weeks. The DN rats were treated with nobiletin of different concentrations (10, 20, and 40 mg/kg/BW). The STZ/Cd-induced DN leads to a significantly increased of the glucose levels, glycosylated haemoglobin, hepatic and kidneyfunction markers, lipid peroxidation levels, and reduction of insulin levels, total haemoglobin, body weight, and antioxidant status markers. Our finding that nobiletin pathological impairment and diminished infiltration of neutrophil in kidney tubules and all biochemical enzymes were near normal levels in DN. More essentially, nobiletin strongly impedes the protein expression of renal nuclear NF-κB p65. Bax protein expression was significantly downregulated and elevated protein expression Bcl-2 was recorded in DN rats. These results show that nobiletin possesses antioxidant as well as anti-diabetic activities and thereby reduces chronic kidney diseases in rats.

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