Article Publish Status: FREE
Abstract Title:

Nootropic Effects ofandseed extracts.

Abstract Source:

Biomed Res Int. 2020 ;2020:8823038. Epub 2020 Dec 9. PMID: 33376745

Abstract Author(s):

Shahana Wahid, Ali Alqahtani, Rafeeq Alam Khan

Article Affiliation:

Shahana Wahid


Dementia and related conditions disturb the ability to perform routine life activities prohibiting a person from making appropriate decisions. Seeds ofandhave been investigated extensively for various pharmacological properties; hence, considering the presence of bioactive compounds, it was assumed that these seed extracts may support the functioning of the central nervous system. Thus, the present study was designed to investigate the short-term and long-term memory-enhancing effects ofandseed extracts in mice by the Morris water maze (spatial learning and memory), stationary rod test, and passive avoidance tests (fear-motivated tests). Ethanol extract of both seeds were prepared by standard procedure and given to animals in the doses of 50 mg/kg, 100 mg/kg, and 200 mg/kg. The results were compared to standard drugs diazepam and imipramine given in the doses of 3 mg/kg and 30 mg/kg, respectively. Extracts of both the seeds were found to possess significant memory and cognition-enhancing effects in mice when tested by passiveavoidance, stationary rod, and water maze tests. Results demonstrate memory and cognition-enhancing effects of these extracts which may be due to the presence of bioactive compounds in these seeds.

Study Type : Animal Study

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Sayer Ji
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