Abstract Title:

Preliminary evaluation of plasticizer and BPA in Tunisian cosmetics and investigation of hazards on human skin cells.

Abstract Source:

Int J Environ Health Res. 2018 Oct ;28(5):491-501. Epub 2018 Jul 16. PMID: 30010399

Abstract Author(s):

Asma Beltifa, Afifa Belaid, Vincenzo Lo Turco, Monia Machreki, Hedi Ben Mansour, Giuseppa Di Bella

Article Affiliation:

Asma Beltifa


In this study, 18 plasticizer (phthalates, adipates, sebacates, and others) and BPA residues in some cosmetic samples collected from Tunisian market are evaluated by micro-matrix solid-phase dispersion combined with GC-MS. In parallel, the impact of these molecules and the cosmetics in the human epithelial cell lines is investigated. The cytotoxic activity of cosmetic extracts is evaluated in vitro against B16 and Hep-2 human skin cell lines using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay. This study shows that the tested cosmetic products could constitute a hazard to the consumer health and wellness and that strict safety analysis on cosmetic products needs to be carried out before they are marketed.

Study Type : In Vitro Study

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