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Article Publish Status: FREE
Abstract Title:

Protective effects of dried maturepeel (Chenpi) and hesperidin on aspirin-induced oxidative damage.

Abstract Source:

J Clin Biochem Nutr. 2021 Mar ;68(2):149-155. Epub 2020 Oct 13. PMID: 33879966

Abstract Author(s):

Yuko Shimamura, Shunsuke Sei, Saori Nomura, Shuichi Masuda

Article Affiliation:

Yuko Shimamura

Abstract:

Here we investigated the inhibitory effects in rats of maturepeel (Chenpi) and its component hesperidin on aspirin-induced oxidative damage. The content of hesperidin in Chenpi extract was approximately 11.4%. Wistar rats were orally administered Chenpi extract or hesperidin (20 mg/kg body weight) and then were orally administered aspirin (200 mg/kg body weight) to induce oxidative damage to the stomach, liver, and kidneys. Such damage was evaluated using the formamidopyrimidine DNA glycosylase-modified comet assay. We also measured the amount of the oxidative marker 8-oxo-7,8-dihydroguanine (8-oxodG) in the stomach. Aspirin-induced damage to the gastric mucosa was evaluated using a bleeding score. Chenpi extract and hesperidin significantly inhibited aspirin-induced oxidative DNA damage. The bleeding score of the aspirin-induced gastric mucosa was significantly reduced by treatment with Chenpi extract and hesperidin. To investigate the effects of Chenpi extract and hesperidin on the analgesic effect of aspirin on ddY mice, we employed the acetic acid-induced writhing response test. Chenpi extract and hesperidin did not significantly affect the analgesic effect of aspirin. These results suggest that Chenpi extract and hesperidin significantly inhibit aspirin-induced gastric mucosal damage.

Study Type : Animal Study

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