Abstract Title:

Evaluation of statins impacts on cognitive function among diabetic patients.

Abstract Source:

Diabetes Metab Syndr. 2019 May - Jun;13(3):1797-1803. Epub 2019 Apr 12. PMID: 31235097

Abstract Author(s):

Mohamed Anwar Hammad, Syed Azhar Syed Sulaiman, Nor Azizah Aziz, Dzul Azri Mohamed Noor

Article Affiliation:

Mohamed Anwar Hammad


AIMS: The study was intended to evaluate the association of cognitive impairment with statins therapy among diabetic outpatients.

METHODS: Mini-Addenbrooke's Cognitive Examination (M-ACE) was conducted for 280 cases in a cross-sectional study at Hospital Pulau Pinang. M-ACE score is 30, and the cut-off score for mild cognitive impairment is ≤ 21 and ≤ 16 for dementia.

RESULTS: The cognitive impairment was distributed among 59 (55.1%) patients with mild cognitive impairment and 48 (44.9%) patients with dementia. From 177 patients using statins, about 80 (45.2%) cases had cognitive impairment. While from 103 statins non-users, only 27 (26.2%) had cognitive impairment. The relative risk of cognitive impairment associated with statins use in diabetic patients is (RR: 1.72, 95% CI: 1.2-2.48) and the excess relative risk is 72.4%. The absolute risk is 19%, and the number needed to harm is 6. Spearman's test indicated a positive association between statins usage and cognitive impairment incidence (r: 0.188, p-value: 0.002). However, Spearman's test showed a non-significant correlation amongst statins and dementia incidence (P-value: 0.587, RR: 1.16, 95% CI: 0.67-2.02).

CONCLUSIONS: Statins therapy has a higher association with cognitive impairment risk than statins-free treatment; however, there is no association between statin use and dementia incidence among diabetic patients.

Study Type : Human Study

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