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Article Publish Status: FREE
Abstract Title:

Tanshinone IIA attenuates demyelination and promotes remyelination in-infected BALB/c mice.

Abstract Source:

Int J Biol Sci. 2019 ;15(10):2211-2223. Epub 2019 Aug 19. PMID: 31592236

Abstract Author(s):

Ying Feng, Feng Feng, Cunjing Zheng, Zongpu Zhou, Meihua Jiang, Zhen Liu, Fukang Xie, Xi Sun, Zhongdao Wu

Article Affiliation:

Ying Feng

Abstract:

BACKGROUND: infection can cause demyelination in the central nervous system, and there is no effective treatment.

METHODS: We used dexamethasone, Tanshinone IIA (TSIIA) and Cryptotanshinone(Two traditional Chinese medicine monomers) in combination with albendazole (AB, a standard anti-helminthic compound) to observe their therapeutic effect on demyelination in-infected mice. Luxol fast blue staining and electron microscope of myelin sheath, Oligodendrocyte (OL) number and myelin basic protein (MBP) expression in brain was detected in above groups.

RESULTS: TSIIA+AB facilitated OL proliferation and significantly increased both myelin sheath thickness and the population of small-diameter axons. In addition, TSIIA treatment inhibited the expression of inflammation-related factors (interleukin [IL]-6, IL-1β, tumor necrosis factor [TNF]-α, inducible nitric oxide synthase [iNOS]) rather than inhibiting eosinophil infiltration in brain. TSIIA also decreased microglial activation and shifted their phenotype from M1 to M2.

CONCLUSIONS: Taken together, these results provide evidence that TSIIA combined with AB may be an effective treatment for demyelination caused byinfection and other demyelinating diseases.

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