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Article Publish Status: FREE
Abstract Title:

Theanine Improves High-Dose Epigallocatechin-3-Gallate-Induced Lifespan Reduction in.

Abstract Source:

Foods. 2021 Jun 17 ;10(6). Epub 2021 Jun 17. PMID: 34204441

Abstract Author(s):

Yuxuan Peng, Shen Dai, Yan Lu, Ligui Xiong, Jianan Huang, Zhonghua Liu, Yushun Gong

Article Affiliation:

Yuxuan Peng

Abstract:

Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. Our previous report showed that induced hormesis was a critical determinant for the promotion of a healthy lifespan in. In the present study, we investigated the anti-aging effects of the main active ingredients in green tea. We found that galloylated catechins (EGCG and epicatechin gallate) could extend the lifespan of, while their metabolites (gallic acid, epicatechin, and epigallocatechin) could not. Interestingly, the combination with theanine, not caffeine, could alleviate the adverse effects induced by high-dose EGCG, including the promotion of lifespan and locomotor ability. This was due to the attenuation of the excess production of reactive oxygen species and the activation of DAF-16. These findings will facilitate further studies on the health benefits of tea active components and their interactions.

Study Type : Animal Study

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Sayer Ji
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