Abstract Title:

Ursolic acid protects against ulcerative colitis via anti-inflammatory and antioxidant effects in mice.

Abstract Source:

Mol Med Rep. 2016 Jun ;13(6):4779-85. Epub 2016 Apr 7. PMID: 27082984

Abstract Author(s):

Baohai Liu, Xuehua Piao, Lianyi Guo, Shanshan Liu, Fang Chai, Leming Gao

Article Affiliation:

Baohai Liu


Ursolic acid (UA) has been reported to have a protective effect in colitis. However, the underlying mechanisms remain to be elucidated. In the present study, experimental ulcerative colitis was induced in male BALB/c mice by the administration of 5% dextran sulfate sodium (DSS) for 7 days, followed by treatment with UA for another 7 days. Hematoxylin&eosin staining was performed to evaluate colon tissue damage, and enzyme assays were used to measure malondialdehyde (MDA) content and superoxide dismutase (SOD) activity in colon homogenate. In addition, serum levels of interleukin (IL)‑1β and tumor necrosis factor (TNF)‑α were measured using an ELISA, and the level of nuclear factor (NF)‑κB p65 in the colonic tissues was assessed by western blotting. The 7‑day DSS administration induced marked colon damage, increased the serum levels of IL‑1β and TNF‑α, increasedMDA content and decreased SOD activity in the colon homogenate. These changes were significantly improved by treatment with UA. UA also reduced the DSS‑stimulated high nuclear level of NF‑κB p65 in the colon tissues. These results demonstrate a protective role of UA in ulcerative colitis, andsuggest that anti-inflammatory and antioxidant activities are involved in the underlying mechanisms.

Study Type : Animal Study

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