Abstract Title:

Nanosized zinc oxide particles induce neural stem cell apoptosis.

Abstract Source:

Nanotechnology. 2009 Mar 18;20(11):115101. Epub 2009 Feb 24. PMID: 19420431

Abstract Author(s):

Xiaoyong Deng, Qixia Luan, Wenting Chen, Yanli Wang, Minghong Wu, Haijiao Zhang, Zheng Jiao

Article Affiliation:

Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, People's Republic of China.


Given the intensive application of nanoscale zinc oxide (ZnO) materials in our life, growing concerns have arisen about its unintentional health and environmental impacts. In this study, the neurotoxicity of different sized ZnO nanoparticles in mouse neural stem cells (NSCs) was investigated. A cell viability assay indicated that ZnO nanoparticles manifested dose-dependent, but no size-dependent toxic effects on NSCs. Apoptotic cells were observed and analyzed by confocal microscopy, transmission electron microscopy examination, and flow cytometry. All the results support the viewpoint that the ZnO nanoparticle toxicity comes from the dissolved Zn(2+) in the culture medium or inside cells. Our results highlight the need for caution during the use and disposal of ZnO manufactured nanomaterials to prevent the unintended environmental and health impacts.

Study Type : In Vitro Study
Additional Links
Problem Substances : Zinc Oxide : CK(18) : AC(0)
Adverse Pharmacological Actions : Neurotoxic : CK(2424) : AC(562)

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